Qhov hnyav -Poob Efficiency ntawm Orlistat
Orlistat yog ib qho muaj zog, tshwj xeeb, thiab ntev - ua yeeb yam inhibitor ntawm plab hnyuv lipases. Hauv kev tshawb fawb tshuaj, Orlistat- ua raws li valerate esterase- ua haujlwm nyob rau hauv lub lumens ntawm lub plab thiab cov hnyuv. Nws tsim cov ntawv cog lus nrog cov serine residues ntawm cov chaw ua haujlwm ntawm lub plab thiab pancreatic lipases, yog li muaj zog tiv thaiv kev ua haujlwm ntawm pancreatic thiab gastrointestinal carboxylesterases thiab phospholipase A2. Qhov kev ua no ua rau qeeb qeeb ntawm hydrolysis ntawm kev noj zaub mov muaj roj rau hauv cov roj fatty acids thiab monoacylglycerols hauv plab hnyuv, yog li thaiv cov hydrolysis thiab nqus ntawm kwv yees li ib -feem peb ntawm cov rog noj. Yog li ntawd, nws txo lub cev rog cia thiab ua rau poob phaus. Clinically, Orlistat yog qhia rau kev kho mob rog rog thiab hyperlipidemia. Feem ntau, qhov pom zoo noj qhov ncauj yog 120 mg peb zaug ib hnub twg, thaum noj mov lossis hauv ib teev tom qab noj mov. Kev poob phaus yuav pib pom tom qab ob lub lis piam ntawm kev kho mob. Cov tshuaj yuav noj tsis tu ncua rau 6 mus rau 12 lub hlis; Txawm li cas los xij, kev nce qib ntau dua 400 mg ib hnub tsis ua rau muaj kev txhim kho ntxiv ntawm nws cov txiaj ntsig kho.
Orlistat Txoj Kev Txhim Kho Ntawm Cov Kab Mob Ntshav Qab Zib
Orlistat tuaj yeem txo qis triglycerides, apolipoprotein B, thiab qhov piv ntawm LDL rau HDL cholesterol. Nws kuj txo qhov cuam tshuam ntawm kev rog rog - cuam tshuam txog cov xwm txheej, xws li insulin tsis kam thiab nce ntshav qabzib. Cov teebmeem ntawm Orlistat ntawm ntau yam ntshav lipid tsis tshwm sim ncaj qha cuam tshuam nrog qhov loj ntawm qhov hnyav poob tiav; Qhov tshwj xeeb pharmacological nyhuv ntawm kev txo cov ntshav lipids tuaj yeem raug ntaus nqi los ntawm kev txo qis hauv kev noj zaub mov muaj roj. Cov txheej txheem tshwm sim hauv qab nws txoj kev txhim kho ntawm kev tswj ntshav qabzib suav nrog kev txo qis hauv - rog hauv plab, txhim kho lipid metabolic profiles, nce insulin rhiab heev, thiab txhim kho cov tshuaj insulin. Tsis tas li ntawd, Orlistat tuaj yeem txo qis cov insulin ceev ceev.